The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric people a lot less than 6 many years of age, since The mixture might lead to lethal respiratory despair On this age inhabitants.
The narcotic antagonist, naloxone hydrochloride, could be administered when major respiratory despair occurs with promethazine and codeine; any depressant consequences of promethazine are certainly not reversed with naloxone. Diazepam can be utilized to regulate convulsions. Avoid analeptics, which can bring about convulsions. Acidosis and electrolyte losses really should be corrected. An increase in temperature or pulmonary problems might signal the need for establishment of antibiotic therapy.
Promethazine hydrochloride happens for a white to faint yellow, pretty much odorless, crystalline powder which slowly and gradually oxidizes and turns blue on extended publicity to air.
Young children ought to be supervised through bicycle Using and various possibly hazardous functions to stop damage. Limit alcoholic beverages. Speak with your doctor In case you are making use of marijuana (cannabis).
Promethazine must be used cautiously in folks with cardiovascular disease or with impairment of liver operate.
To lower your chance, your physician ought to have you take the smallest dose that works, and take it to the shortest feasible time. See also How to Use segment To find out more about dependancy.
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Antihistamines and codeine are the two contraindicated to be used inside the treatment method of decreased respiratory tract signs or symptoms, together with asthma.
Codeine and its salts are well absorbed following the two oral and parenteral administration. Codeine is about 2/three as productive orally as parenterally. Codeine is metabolized primarily within the liver by enzymes in the endoplasmic reticulum, exactly where it undergoes 0-demethylation, N-demethylation, and partial conjugation with glucuronic acid.
Diligently evaluate the dose employing a Distinctive measuring unit/spoon. Never make use of a home spoon as you may well not get the proper dose.
Epinephrine - Due to the opportunity for promethazine to reverse epinephrine’s vasopressor result, epinephrine really should not be utilized to treat hypotension connected with promethazine overdose.
Ambulatory patients ought to be instructed to stay away from engaging in such actions until finally it is thought that they do not grow to Promethazine codeine syrup be drowsy or dizzy from promethazine and codeine therapy. Pediatric individuals needs to be supervised to avoid possible hurt in bike riding or in other harmful pursuits.
Codeine: A study in rats and rabbits reported no teratogenic influence of codeine administered during the period of organogenesis in doses ranging from five to one hundred twenty mg/kg. From the rat, doses at the one hundred twenty-mg/kg stage, while in the poisonous array with the adult animal, were being associated with a rise in embryo resorption at time of implantation.
If each medicines are prescribed together, your health care provider may possibly alter the dose or how often you utilize one particular or equally of your medicines.